News

  • Study suggests simple way to predict preterm births

    09.04.2017

    Test of cervical mucus may reveal pregnant women’s risk of going into labor too early… Read more 


  • Team gathers unprecedented data on atmosphere’s organic chemistry

    09.04.2017

    Colorado forest study provides clearest-ever picture of gases released into the atmosphere and how they change… Read more


  • MIT has been awarded the NIH Translational Center of Tissue Chip Technologies

    08.09.2017

    A large percentage of drug candidates fail at the clinical trial stage due to a lack of efficacy and unacceptable toxicity, primarily because the in vitro cell culture models and in vivo animal models commonly used in preclinical studies provide limited information about how a drug will affect human physiology. The need for more physiologically relevant in vitro systems for preclinical efficacy and toxicity testing has led to a major effort to develop “Microphysiological Systems (MPS)”, aka tissue chips (TC), based on engineered human tissue constructs. The MPS development process requires an initial assessment of viability and functionality, followed by an examination of the MPS response to various stimuli, including drugs, environmental toxins, and disease-related cues. These extensive development efforts take place mainly in the developer’s lab, and the reproducibility of the MPS results are rarely assessed by an independent research group or transferred to industry partners for use in drug development.

    Although there is a need for more physiologically-relevant preclinical testing technologies, the transition of MPS technologies from academia to industry remains challenging. Successful transfer and deployment of MPS technologies requires quantitative characterization and validation of the systems, preferably by an independent and unbiased external testing facility. Translational Center of Tissue Chip Technologies (TC2T) has been established to bridge between academic research and development and industrial application of MPS technologies via providing unbiased testing and validation of MPS technologies.

    TC2T takes a holistic and mechanistic approach—based on quantitative systems pharmacology (QSP)—that combines quantitative experimental biology, computational biology, and biostatistics to achieve unbiased characterization of these complex systems and translation of experimental insights to clinical outcomes. Our translational systems pharmacology team at MIT includes tissue engineers, experimentalists, and computational biologists and serves as the core of the testing center to identify adverse effects of pharmaceutical compounds and environmental toxin on human organs.

    Importantly, researchers concerned about environmental exposures are faced with many of the same challenges as those in drug development. They need to know what is toxic and what is not so that decisions can be made about protection and remediation. The resources being developed by TC2T can ultimately be used for critical problems in environmental health.

    For more information on TC2T please visit their website.


  • Passamaquoddy Tribe Hosts CEHS Community Forum and Workshop in Pleasant Point, Maine

    06.26.2017

    by Kathleen M. Vandiver, MIT CEHS COE2C Director

    Recognizing that people in their communities wanted to learn how to write more effective grant proposals, and they might not have the funds to travel, the Passamaquoddy Tribe decided to organize an event in Pleasant Point, Maine.  The Sipayik Environmental Department included Asha Ajmani, William Longfellow and Christopher Johnson, invited CEHS Director John Essigmann to come to Pleasant Point to teach a workshop in the morning and to lead a community forum in the afternoon.  The event took place at the tribe’s Koluscap Community Center on March 10, 2017 with 30 people in attendance.  This community engagement event was also designed to help tribal and community members recognize how a local issue of concern might be transformed into a grant proposal that could potentially improve public health.

    So who came to this event?  Quite a broad variety of people from many organizations attended!  Many were affiliated with the Passamaquoddy from Pleasant Point and Township, and they including members from tribal government, the health center, and the environmental department.  Members of the Penobscot Tribe came from furthest away, from Indian Island near Bangor, Maine.  Non-tribal individuals from local coast businesses as well as town officials participated, including a participant from a whale watching company and some businesses in Eastport, Maine.  This broad participation was accomplished by resourceful advertising– through word of mouth, the tribal newsletter on Facebook, email, and by placing flyers on tribal bulletin boards, doors, and all around downtown Eastport. Flyers were also sent to the Indian Township’s Environmental Department and the Penobscot Natural Resources Department where their directors posted them.

    John Essigmann, CEHS Center Director, taught the art and the essentials of proposal writing on that morning in March.  His presentation was organized around the following topics: how to create online searches for government and private opportunities for grant applications; how to find papers in the scientific literature and news websites relevant to a possible application.  After that, he focused on teaching about the writing techniques and the review processes, specifically on how a grant proposal is structured and how a proposal will be reviewed by a group of peers and/or community advocates. 

    Essigmann offered some key take-home messages. For instance, he emphasized the critical importance of the abstract and specific aims at the beginning of the proposal, stressing these components must to be well-designed to capture and maintain the attention of the reviewers from the onset. Additionally he stated that these sections could be enhanced by an introductory figure to communicate the vision behind the proposed project.    

    The afternoon session was organized as a community forum.  Essigmann invited participants to raise local environmental health issues of concern so that together they might practice how to reframe these issues into a proposal.  While guiding the discussion, Essigmann also explained what agencies might provide support for the ideas that were raised. Here is one example of a problem of local importance to the Passamaquoddy.  During the Spring, Native Americans traditionally eat young ferns called fiddleheads that are very abundant in the fields and forests at this time.  Ferns, however, reportedly accumulate heavy metals, including arsenic, nickel, mercury and cadmium and that now raises concern.  While studies of the health effects of ferns were discussed, Essigmann and the tribe formulated a very practical early-stage proposal that might catch the interest of a potential funder. 

    The analytical methods that could be applied in the laboratory to detect the metals in the ferns were also presented.  Since metals bio-accumulate in the ferns from the soil, it was reasoned that ferns collected in some areas might have less metal content than ferns collected elsewhere. The participants then helped to design a three-year study specifically because grants are typically awarded for that length of time.  Participants were eager to provide the citizen science expertise.  They could help the environmental laboratory by carefully collecting and labeling the fern samples from different locations. 

    Importantly, some members of the Sipayik Environmental Department have already received training at the MIT CEHS Core Facility laboratories. Consequently, the department could bring the fern samples to MIT to analyze the samples for metal content using MIT’s inductively coupled plasma mass spectrometer (ICP-MS).  The goal would be to publish these findings in the scientific literature.  Moreover, these results could inform the tribe’s fern harvesting practices and, it is hoped, toimprove peoples’ long-term health.  Taken together, these outreach and engagement activities demonstrate how a potential research proposal, focused on a local issue of concern, might engage citizens and tribal environmental members in improving public health. 


  • Bathe’s Latest Advances Open Doors…

    06.07.2017

    To learn more about Professor Bathe's research, click here

    Mark Bathe’s Latest Advances Open Doors not only for Solving Clinical Problems, but also Provides Novel Avenues for using Genetic Engineering to Study Problems in Environmental Health

    To read more about this news, please click here.

     


  • Detecting mutations could lead to earlier liver cancer diagnosis

    04.25.2017

    New technique can reveal exposure to aflatoxin, a potent carcinogen, before tumors develop Read more


  • New technology could offer cheaper, faster food testing

    04.05.2017

    Specialized droplets interact with bacteria and can be analyzed using a smartphone.


  • Tackling the health effects of climate change

    03.15.2017

    Experts predict potentially dire health effects from climate change and say that negative effects are already occurring. But health systems and health professionals can play a key role in protecting the public, according to experts from Harvard T.H. Chan School of Public Health.

    In an opinion article published March 1, 2017, in the New England Journal of Medicine, David Hunter, Vincent L. Gregory Professor in Cancer Prevention, Ashish Jha, K.T. Li Professor of International Health and director of the Harvard Global Health Institute, and Howard Frumkin of the University of Washington outlined some of the worrisome scenarios posed by climate change—more heat waves, higher ozone levels, larger and longer forest fires, more severe storms, upticks in vector-borne diseases, and food shortages—all of which could lead to severe health impacts.

    Health care systems can help by anticipating and preparing for climate-related health threats and by reducing their own greenhouse-gas emissions, the authors wrote.

    Health professionals—trusted communicators about health risks and their management—can help, too. They can explain the risks of climate change to their patients and the public, as well as the benefits of trying to mitigate and adapt to it.

    “As opinion leaders, we can remind our communities that climate change is verified by strong science, is already harming health, and is solvable if we act soon,” the authors wrote. “And we can emphasize the good news that tackling climate change will benefit not only the health of the planet but also the health of its peoples.”

    Read the New England Journal of Medicine article: Preventive Medicine for the Planet and Its Peoples.


  • CEHS 2017 Poster Session Results

    01.25.2017

    We are delighted to report that the Poster Session was a great success with excellent attendance and exciting science and engineering.  The winners this year are:

    Graduate Student Category:

    • First Place: Jonathan Franklin (Kroll Lab)
    • Second Place: Le “Lizzie” Ngo (Engelward Lab)
    • Tied for Third Place: Jules Stephan (Nolan Lab) and Daniel Rothenberg (White Lab)

    Postdoctoral Scholar Category:

    • First Place: Supawadee “Apple” Chawanthayatham (Essigmann Lab)
    • Second Place: Yehuda Brody (Blainey Lab)
    • Tied for Third Place: Victor Hernandez-Gordillo (Griffith Lab) and Annelien Zweemer (Lauffenburger Lab)

    If you were unable to attend this year, please be sure to join us next year! The poster session was made possible by support from the Center for Environmental Health Sciences, the Department of Biological Engineering, and the Myriam Marcelle Znaty Memorial Research Fund.

    http://news.mit.edu.ezproxyberklee.flo.org/2017/center-environmental-health-sciences-selects-poster-winners-0223


  • Cracking the code for dormant bacteria

    11.17.2016

    Newly discovered genetic code controls bacterial survival during infections.