Past Events

Amira Elbakry (D’Andrea Lab, Dana Farber Cancer Institute): CHAMP1 and POGZ promote the protection and restart of stalled replication forks

Katelyn Rioux (New England Bio Labs): Archaeal MutT enzymology and biology

Benjamin J. Ryan (Engelward Lab, MIT): Structural Basis of DNA Polymerase Beta Gap Filling Activity within the Nucleosome

Einthavy Arunachalam (Engelward Lab, MIT): Using Oncolytic Virotherapy of Convert Low-Mutational Burden and Immunotherapy-Resistant Prostate Tumours into T-cell-Inflamed Microenvironments

Nina Gubina (Essigmann Lab, MIT): Mutagenic effects of chronic low dose exposure to N-nitrosodimethylamine in wild type mice

Hassan Bukhari (Feany Lab, Brigham and Women’s Hospital/Harvard Medical School): A Drosophila knock-in tauopathy model analyzed at single-cell resolution reveals a fundamental role of tau in regulating mitochondrial function and DNA repair

Carlos Mendez-Dorantes (Burns Lab, Dana Farber Cancer Institute): Investigating the chromosomal instability signature of LINE-1 expression

Gerardo Perez Goncalves (Drennan Lab, MIT): Biochemical and biophysical studies of a novel interaction partner of human ribonucleotide reductase

Thomas L. Clarke (Clarke Lab, Boston University): ZNF280A links DNA double-strand break repair to 22q11.2 distal deletion syndrome

Alexandre André B A da Costa (D’Andrea Lab, Dana Farber Cancer Institute): USP1 Inhibitors kill BRCA1-deficient tumor cells by inducing single strand DNA gaps

Ryan McGinty (Sunyaev Lab, Harvard Medical School): Modeling replication slippage explains short tandem repeat lengths in the human genome

Aleem Syed (D’Andrea Lab, Dana Farber Cancer Institute): Allosteric inhibitors of DNA polymerase theta ATPase activity

Daniel Laverty (Nagel Lab, Harvard T.H. Chan School of Public Health): A mismatch repair-independent mechanism resolves insertion-deletion loops in transcribed DNA

Vladimir Seplyarskiy (Sunyaev Lab, Harvard Medical School): Evolution of mutational processes in mammals

Felix Zhou (Haber Lab, Brandeis University): The role of Arp2/3 and myosins in double-strand break mobility is S. cerevisiae

Sateja Paredkar (Bindra Lab, Yale University): PARG inhibition leads to the formation of cytotoxic PARP1 aggregates